Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs
AN Salt, EB King, JJ Hartsock, RM Gill, SJ O'Leary - Hearing research, 2012 - Elsevier
It has been widely believed that drug entry from the middle ear into perilymph occurs
primarily via the round window (RW) membrane. Entry into scala vestibuli (SV) was thought
to be dominated by local, inter-scala communication between scala tympani (ST) and SV
through permeable tissues such as the spiral ligament. In the present study, the distribution
of the ionic marker trimethylphenylammonium (TMPA) was compared following intracochlear
injections or applications to the RW niche, with or without occlusion of the RW membrane or …
primarily via the round window (RW) membrane. Entry into scala vestibuli (SV) was thought
to be dominated by local, inter-scala communication between scala tympani (ST) and SV
through permeable tissues such as the spiral ligament. In the present study, the distribution
of the ionic marker trimethylphenylammonium (TMPA) was compared following intracochlear
injections or applications to the RW niche, with or without occlusion of the RW membrane or …
