MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons
SR Tymanskyj, TME Scales… - Molecular and Cellular …, 2012 - Elsevier
The microtubule-associated protein MAP1B is known to have important roles in neuronal
development, particularly during neuronal migration and axonogenesis, but its precise
molecular actions are unknown. We used RNA interference silencing of protein expression
to specifically knock down MAP1B in cultured embryonic rat cortical neurons. Reduction of
MAP1B in these neurons is associated with several abnormal morphological phenotypes
including the production of more highly branched and slower growing axons than normal …
development, particularly during neuronal migration and axonogenesis, but its precise
molecular actions are unknown. We used RNA interference silencing of protein expression
to specifically knock down MAP1B in cultured embryonic rat cortical neurons. Reduction of
MAP1B in these neurons is associated with several abnormal morphological phenotypes
including the production of more highly branched and slower growing axons than normal …
