Neurofilament antibodies and spiral ganglion neurons of the mammalian cochlea

AM Berglund, DK Ryugo - Journal of comparative neurology, 1991 - Wiley Online Library
AM Berglund, DK Ryugo
Journal of comparative neurology, 1991Wiley Online Library
The spiral ganglia of the cat, gerbil, mouse, rat, and human were immunohistochemically
stained with various monoclonal neurofilament antibodies. Three antibodies to the 200-kD
neurofilament protein (R-3, Dräger et al.,'84; ICN anti-200, clone NE14, Debus et al.,'83; RT-
97, Wood and Anderton,'81) labeled the somata of type II spiral ganglion neurons but not
those of type I ganglion neurons. In the extreme base of the cochlea of cats, mice and rats,
there was intense labeling of a few (< 0.5% of the total ganglion population) large neurons …
Abstract
The spiral ganglia of the cat, gerbil, mouse, rat, and human were immunohistochemically stained with various monoclonal neurofilament antibodies. Three antibodies to the 200-kD neurofilament protein (R-3, Dräger et al.,'84; ICN anti-200, clone NE14, Debus et al.,'83; RT-97, Wood and Anderton,'81) labeled the somata of type II spiral ganglion neurons but not those of type I ganglion neurons. In the extreme base of the cochlea of cats, mice and rats, there was intense labeling of a few (< 0.5% of the total ganglion population) large neurons resembling type I ganglion neurons.
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