Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2
Y Tona, DK Wu - Elife, 2020 - elifesciences.org
Directional sensitivity of hair cells (HCs) is conferred by the aymmetric apical hair bundle,
comprised of a kinocilium and stereocilia staircase. The mother centriole (MC) forms the
base of the kinocilium and the stereocilia develop adjacent to it. Previously, we showed that
transcription factor Emx2 reverses hair bundle orientation and its expression in the mouse
vestibular utricle is restricted, resulting in two regions of opposite bundle orientation (Jiang
et al., 2017). Here, we investigated establishment of opposite bundle orientation in …
comprised of a kinocilium and stereocilia staircase. The mother centriole (MC) forms the
base of the kinocilium and the stereocilia develop adjacent to it. Previously, we showed that
transcription factor Emx2 reverses hair bundle orientation and its expression in the mouse
vestibular utricle is restricted, resulting in two regions of opposite bundle orientation (Jiang
et al., 2017). Here, we investigated establishment of opposite bundle orientation in …
Live imaging of hair bundle polarity acquisition in the mouse utricle demonstrates a critical timeline for transcription factor Emx2
Y Tona, DK Wu - bioRxiv, 2020 - biorxiv.org
The asymmetric hair bundle on top of hair cells (HCs), comprises a kinocilium and
stereocilia staircase, dictates HC directional sensitivity. The mother centriole (MC) forms the
base of the kinocilium, where stereocilia are subsequently built next to it. Previously we
showed that transcription factor Emx2 reverses hair bundle orientation and its expression in
the mouse vestibular utricle is restricted, resulting in two regions of opposite bundle
orientation. Here, we investigated establishment of opposite bundle orientation in embryonic …
stereocilia staircase, dictates HC directional sensitivity. The mother centriole (MC) forms the
base of the kinocilium, where stereocilia are subsequently built next to it. Previously we
showed that transcription factor Emx2 reverses hair bundle orientation and its expression in
the mouse vestibular utricle is restricted, resulting in two regions of opposite bundle
orientation. Here, we investigated establishment of opposite bundle orientation in embryonic …
