Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects
KEC Bouter, GJ Bakker, E Levin… - Clinical and …, 2018 - journals.lww.com
Background: Gut microbiota-derived short-chain fatty acids (SCFAs) have been associated
with beneficial metabolic effects. However, the direct effect of oral butyrate on metabolic
parameters in humans has never been studied. In this first in men pilot study, we thus treated
both lean and metabolic syndrome male subjects with oral sodium butyrate and investigated
the effect on metabolism. Methods: Healthy lean males (n= 9) and metabolic syndrome
males (n= 10) were treated with oral 4 g of sodium butyrate daily for 4 weeks. Before and …
with beneficial metabolic effects. However, the direct effect of oral butyrate on metabolic
parameters in humans has never been studied. In this first in men pilot study, we thus treated
both lean and metabolic syndrome male subjects with oral sodium butyrate and investigated
the effect on metabolism. Methods: Healthy lean males (n= 9) and metabolic syndrome
males (n= 10) were treated with oral 4 g of sodium butyrate daily for 4 weeks. Before and …
