Permissiveness of Kupffer cells for simian immunodeficiency virus (SIV) and morphological changes in the liver of rhesus monkeys at different periods of SIV infection
Y Persidsky, AM Steffan, JL Gendrault, B Hurtrel… - Hepatology, 1995 - Elsevier
The pathogenesis of liver injury, which remains unclear in the course of human
immunodeficiency virus infection, can be investigated in simian immunodeficiency virus-
infected macaques, which develop an immunodeficiency disease resembling human
acquired immune deficiency syndrome (AIDS). We studied the livers of 21 monkeys infected
with simian immunodeficiency virus (SIV, mac251) for 4 days to 39 months and detected
viral antigens in Kupffer cells, macrophages, and lymphocytes in 65% of the livers tested …
immunodeficiency virus infection, can be investigated in simian immunodeficiency virus-
infected macaques, which develop an immunodeficiency disease resembling human
acquired immune deficiency syndrome (AIDS). We studied the livers of 21 monkeys infected
with simian immunodeficiency virus (SIV, mac251) for 4 days to 39 months and detected
viral antigens in Kupffer cells, macrophages, and lymphocytes in 65% of the livers tested …
