[HTML][HTML] Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial
Intestinal mucosal immune system is an early target for human immunodeficiency virus type
1 (HIV-1) infection, resulting in CD4+ T-cell depletion, deterioration of gut lining, and fecal
microbiota composition. We evaluated the effects of a prebiotic oligosaccharide mixture in
highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults. In a pilot double-
blind, randomized, placebo-controlled study, 57 HAART-naive HIV-1-infected patients
received a unique oligosaccharide mixture (15 or 30 g short chain galactooligosaccharides …
1 (HIV-1) infection, resulting in CD4+ T-cell depletion, deterioration of gut lining, and fecal
microbiota composition. We evaluated the effects of a prebiotic oligosaccharide mixture in
highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults. In a pilot double-
blind, randomized, placebo-controlled study, 57 HAART-naive HIV-1-infected patients
received a unique oligosaccharide mixture (15 or 30 g short chain galactooligosaccharides …
