Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors
D Xue, T Tabib, C Morse, R Lafyatis - Journal of dermatological science, 2020 - Elsevier
Background The heterogeneous functions of dermal myeloid cells in antigen presentation,
and scavenging pathogens and cell debris places them centrally in cutaneous inflammation.
Single cell transcriptomics can provide new understanding of the heterogeneity and function
of yet incompletely understood human dermal myeloid cell subsets. Objective Investigate the
transcriptome landscape of myeloid cells in healthy human skin. Methods Single cell RNA-
sequencing was performed on skin biopsies from ten healthy donors and analyzed to …
and scavenging pathogens and cell debris places them centrally in cutaneous inflammation.
Single cell transcriptomics can provide new understanding of the heterogeneity and function
of yet incompletely understood human dermal myeloid cell subsets. Objective Investigate the
transcriptome landscape of myeloid cells in healthy human skin. Methods Single cell RNA-
sequencing was performed on skin biopsies from ten healthy donors and analyzed to …
