Background In previous human skin single-cell data, inflammatory cells constituted only a
small fraction of the overall cell population, such that functional subsets were difficult to
ascertain. Objective Our aims were to overcome the aforesaid limitation by applying single-
cell transcriptomics to emigrating cells from skin and elucidate ex vivo gene expression
profiles of pathogenic versus regulatory immune cell subsets in the skin of individuals with
psoriasis. Methods We harvested emigrating cells from human psoriasis skin after …