Association of the numbers of CD163+ cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma
M Sugaya, T Miyagaki, H Ohmatsu, H Suga… - Journal of …, 2012 - Elsevier
BACKGROUND: Classically activated macrophages produce IL-12, IL-23, and TNF-α,
whereas alternatively activated macrophages (M2 cells) produce IL-10 and express several
receptors such as mannose receptor and CD163. Tumor-associated macrophages exhibit
M2 phenotype, whose presence has been associated with poor prognosis in various tumors.
OBJECTIVES: To investigate distribution of CD163+ cells in lesional skin and serum levels
of soluble CD163 (sCD163) in patients with cutaneous T cell lymphoma (CTCL), atopic …
whereas alternatively activated macrophages (M2 cells) produce IL-10 and express several
receptors such as mannose receptor and CD163. Tumor-associated macrophages exhibit
M2 phenotype, whose presence has been associated with poor prognosis in various tumors.
OBJECTIVES: To investigate distribution of CD163+ cells in lesional skin and serum levels
of soluble CD163 (sCD163) in patients with cutaneous T cell lymphoma (CTCL), atopic …
