The disruption and hyperpermeability of blood-labyrinth barrier mediates cisplatin-induced ototoxicity
J Gu, L Tong, X Lin, Y Chen, H Wu, X Wang, D Yu - Toxicology letters, 2022 - Elsevier
The ototoxic mechanisms of cisplatin on the organ of Corti and spiral ganglion neurons have
been extensively studied, while few studies have been focused on the stria vascularis (SV).
Herein, we verified the functional and morphological impairment in SV induced by a single
injection of cisplatin (12 mg/kg, IP), represented by a reduction in Endocochlear Potentials
(EP) and strial atrophy, and explored underlying mechanisms. Our results revealed
increased extravasation of chromatic tracers (Evans blue dye and FITC-dextran) around …
been extensively studied, while few studies have been focused on the stria vascularis (SV).
Herein, we verified the functional and morphological impairment in SV induced by a single
injection of cisplatin (12 mg/kg, IP), represented by a reduction in Endocochlear Potentials
(EP) and strial atrophy, and explored underlying mechanisms. Our results revealed
increased extravasation of chromatic tracers (Evans blue dye and FITC-dextran) around …
