Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site
NE Franklin, GS Taylor, PO Vacratsis - Journal of Biological Chemistry, 2011 - ASBMB
MTMR2 is a member of the myotubularin family of inositol lipid phosphatases, a large
protein-tyrosine phosphatase subgroup that is conserved from yeast to humans.
Furthermore, the peripheral neuromuscular disease Charcot-Marie Tooth disease type 4B
has been attributed to mutations in the mtmr2 gene. Because the molecular mechanisms
regulating MTMR2 have been poorly defined, we investigated whether reversible
phosphorylation might regulate MTMR2 function. We used mass spectrometry-based …
protein-tyrosine phosphatase subgroup that is conserved from yeast to humans.
Furthermore, the peripheral neuromuscular disease Charcot-Marie Tooth disease type 4B
has been attributed to mutations in the mtmr2 gene. Because the molecular mechanisms
regulating MTMR2 have been poorly defined, we investigated whether reversible
phosphorylation might regulate MTMR2 function. We used mass spectrometry-based …
