Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa
K Navrazhina, JW Frew, P Gilleaudeau… - Journal of Allergy and …, 2021 - Elsevier
Background Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic,
painful, and burdensome inflammatory disease manifesting in nodules and abscesses, with
progression to chronically draining tunnels in later-stage disease. Objective We sought to
determine whether HS tunnels are immunologically active participants in disease activity.
Methods Skin biopsy specimens were obtained by using ultrasound guidance in untreated
patients with HS and those enrolled in an open-label study of brodalumab (ClinicalTrials …
painful, and burdensome inflammatory disease manifesting in nodules and abscesses, with
progression to chronically draining tunnels in later-stage disease. Objective We sought to
determine whether HS tunnels are immunologically active participants in disease activity.
Methods Skin biopsy specimens were obtained by using ultrasound guidance in untreated
patients with HS and those enrolled in an open-label study of brodalumab (ClinicalTrials …
