Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa
R Sabat, D Šimaitė, JE Gudjonsson… - Journal of Allergy and …, 2023 - Elsevier
Background Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized
by painful inflamed nodules, abscesses, and pus-draining tunnels appearing in axillary,
inguinal, and perianal skin areas. HS lesions contain various types of immigrated immune
cells. Objective This study aimed to characterize mediators that support lesional B/plasma
cell persistence in HS. Methods Skin samples from several cohorts of HS patients and
control cohorts were assessed by mRNA sequencing, quantitative PCR on reverse …
by painful inflamed nodules, abscesses, and pus-draining tunnels appearing in axillary,
inguinal, and perianal skin areas. HS lesions contain various types of immigrated immune
cells. Objective This study aimed to characterize mediators that support lesional B/plasma
cell persistence in HS. Methods Skin samples from several cohorts of HS patients and
control cohorts were assessed by mRNA sequencing, quantitative PCR on reverse …
