IL-35 promoted STAT3 phosphorylation and IL-10 production in B cells, but its production was reduced in patients with coronary artery diseases
Z Zhu, Y Zhang, J Ye, X Wang, X Fu, Y Yin, J Wen… - Human Immunology, 2018 - Elsevier
Abstract Interleukin (IL)-35 is a heterodimeric cytokine composed of the IL-12A subunit and
the Epstein-Barr virus induced gene 3 (EBI3) subunit. Binding of IL-35 with IL-12 receptor
subunit beta 2 (IL-12RB2) and IL-6 signal transducer (IL-6ST) occupies the binding sites of
IL-6, IL-12, and IL-27 and prevents their signal transduction. IL-35 is also shown to promote
the development of regulatory T cells (Tregs) and regulatory B cells (Bregs). In this study, we
investigated B cell-mediated IL-35 production in patients with coronary artery disease …
the Epstein-Barr virus induced gene 3 (EBI3) subunit. Binding of IL-35 with IL-12 receptor
subunit beta 2 (IL-12RB2) and IL-6 signal transducer (IL-6ST) occupies the binding sites of
IL-6, IL-12, and IL-27 and prevents their signal transduction. IL-35 is also shown to promote
the development of regulatory T cells (Tregs) and regulatory B cells (Bregs). In this study, we
investigated B cell-mediated IL-35 production in patients with coronary artery disease …
