A large variety of molecular pathways in melanoma progression suggests that no individual
molecular alteration is crucial in itself. Our aim was to define the molecular alterations
underlying metastasis formation. Gene expression profiling was performed using microarray
and qRT-PCR to define alterations between matched primary and metastatic melanoma cell
lines. These data were integrated with publicly available unmatched tissue data. The
invasiveness of cell lines was determined by Matrigel invasion assays and invasive clones …