The pathophysiology of atopic dermatitis is complex and multifactorial, involving elements of
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated
hypersensitivity, and environmental factors. Loss of function mutations in filaggrin have been
implicated in severe atopic dermatitis due to a potential increase in trans-epidermal water
loss, pH alterations, and dehydration. Other genetic changes have also been identified
which may alter the skin's barrier function, resulting in an atopic dermatitis phenotype. The …

Atopie dermatitis (AD) is a chronically relapsing inflammatory skin disease that frequently
occurs in patients with a personal or family history of asthma and/or allergic rhinitis. Chronic
AD may result in significant morbidity, including hospitalization for control of skin disease
and infection, school days lost, psychologic trauma from physical disfigurement,
occupational disability, and the need for long-term medications. Patients with AD have an
increased susceptibility to cutaneous infections with bacteria, viruses, and fungi. Patients …

Background Atopic dermatitis is the most common chronic inflammatory skin disorder,
affecting up to 20% of children and 10% of adults in industrialized countries. This highly
debilitating condition poses a considerable burden to both the individual and society at
large. The pathophysiology of atopic dermatitis is complex, encompassing both genetic and
environmental risk factors. Methods This is a narrative review based on a systematic
literature search. Conclusions Dysregulation of innate and adaptive immunity plays a key …