Mitochondria control bioenergetics and cell fate decisions, but how they influence nuclear
gene expression is understood poorly. Here, we show that deletion or reduction in the levels
of cyclophilin D (CypD, also called Ppif), a mitochondrial matrix peptidyl prolyl isomerase
and apoptosis regulator, results in increased cell proliferation and enhanced cell migration
and invasion. These responses are associated with extensive transcriptional changes,
modulation of a chemokine/chemokine receptor gene signature, and activation of the …